The first car camp on the Zagreb-Lipovac route has been opened

first_imgToday, in the village of Osekovo near Popovača, only 65 km from Zagreb, the first car camp was opened along the Zagreb-Lipovac highway.The construction of the car camp was supported by the local authorities and the Ministry of Tourism of the Republic of Croatia and the Croatian National Tourist Board, and it was officially opened in the presence of numerous tourist workers and guests from the county. “This auto camp represents a significant contribution to the development of tourism in the area not only of this, but also of other counties of continental Croatia. We hope that its capacities, with good promotion of both local and central tourism organizations, will be adequately filled”, Said Jasmina Rakić Horvar, President of the Croatian Rural Tourism Association, whose main goal is to create a more favorable environment for rural tourism in rural areas.The opening was accompanied by a rich program of local cultural and artistic societies, which could be enjoyed by the first guests of the camp from the Netherlands. Auto camp is a private investment Rural tourism Bistricki which have been successfully engaged in rural tourism for seven years, and in addition to vacation and nature, are focused on a rich offer of domestic healthy organic food. On 5000 m2 of yard and 20 m000 of additional space, each guest can live with life in the countryside with a tour of a collection of tools over 2 years old and with domestic animals that complement the experience of traditional rural life on the farm stand out from Rural Tourism Bistrički.last_img read more

Read More »

Discovering the brain’s memory switch

first_imgShare on Twitter LinkedIn Share Email Share on Facebookcenter_img Pinterest Scientists have recorded evidence of the brain turning off its memory inhibitor to make new memories.In 1953, a man named Henry Molaison underwent a surgery which removed most of his hippocampus in an attempt to cure his epileptic seizures.  The surgery was a qualified success though, because in addition to curing him of seizures he also lost the ability to form new long term memories.  It was Molaison’s memory problems that led doctors to conclude that the hippocampus was the part of the brain responsible for long term memory.Since then, the hippocampus has been studied frequently and it is generally accepted that it plays an important role in memory.  What haven’t been studied enough are the physical processes that occur when new memories form.  Scientists at the IBS Center for RNA Research and Department of Biological Sciences at Seoul National University in South Korea have discovered multiple repressive mechanisms in the hippocampus during memory formation and published their findings in this month’s issue of Science. IBS Center for RNA Research used a tool called Ribosome profiling (RPF) as well as RNA-seq to analyze mouse hippocampi. In contrast to the widely held belief that memory formation relies on protein formation in the brain, the research group found that the genes encoding hippocampal ribosomal subunits, the organelle responsible for translating mRNA into protein, are translationally suppressed. Additionally, they found that hippocampal levels of translating ribosomes are much lower than those from other organs (livers, testes and kidneys).They carried out RPF and RNA-seq with the mouse hippocampi after contextual fear conditioning by comparing them to an untested control group after 5,10 and 30 minutes and 4 hours post-conditioning. Through the analysis of the data, the research offers insight into translational and transcriptional regulations in the brain during memory formation at the genomic scale.  The observations showed two types of repressive events were induced after learning: an initial wave of transient translational regulation at around 5 to 10 minutes and the suppression of genes through decreases of mRNA levels after 30 minutes, which continued through 4 hours.Why did this happen?  It seems that in order to make new memories, the brain needs to turn off genetic processes which act to inhibit memories from being formed.  IBS researcher Jun Cho explains, “Some of these genes might be ‘memory suppressor genes’ that need to be down-regulated for memory formation.”  After analyses it was found that Nrsn1, one of the newly identified genes undergoing rapid translational repression, may act as a suppressor of long-term memory formation.  Additionally, activating estrogen receptor ESR1 in the hippocampus also impaired memory formation.When an animal experiences no stimulus in an environment the hippocampus undergoes gene repression which prevents the formation of new memories.  Upon the introduction of a stimulus, the hippocampus’ repressive gene regulation is turned off allowing for new memory creation, and as Jun Cho puts it, “Our study illustrates the potential importance of negative gene regulation in learning and memory”.This work wouldn’t have been possible without the use of RPF, which allows sensitive and quantitative measurement of translation at the genomic scale.  RPF yields quantitative information about the mRNAs undergoing translation and this was the first time it was used for an application involving the brain and memory formation.  In the future, RPF could be used in other applications in order to gain a greater understanding of translation. More than anything else, this research highlights that new approaches need to be taken to understand the yet-unappreciated gene-regulatory events during memory formation.last_img read more

Read More »

Saturday’s Virtual Los Alamos ScienceFest Discovery Day 2020 Features STEM Advocate Miss America 2020, Live Demos And Discussions

first_imgScienceFest News:The first virtual Los Alamos ScienceFest Discovery Day is 10 a.m. to 3 p.m. Saturday, July 11.Attendees can login to the event app to view exhibitor profiles, engage in online content and videos, sign up for a chance to win raffle prizes and giveaways, and even tune in for live virtual discussions and demos.The day will kick off at 10 a.m. with a live demo and Q&A from Miss America 2020, Miss Camille Schrier, a STEM advocate. Details for this event and others can be found on the app (desktop or mobile) as well as through the ScienceFest website in the Event Schedule section by clicking on “View Schedule and Attend Virtually.” Links to live discussions also will be posted directly in Exhibitor Virtual Booths. Registration is requested in advance for some activities.Exhibitors expected to go live are noted as follows:10:00 a.m. LIVE with Miss America 2020, Miss Camille Schrier – A Virtual “Blood Bubbles” Demonstration and Classroom Chat Miss Camille Schrier, a STEM advocate who holds biochemistry and systems biology degrees, will engage with students about pH, the blood, and why we breathe in this fun demonstration. Have a chance to ask questions! Register Here10-10:45 a.m. LIVE with TechSource 10-12 p.m. Live with RoboRAVE International 10-3 p.m. Live with UbiQD11 a.m. Live with The Education Plan 11-1 p.m. Live with the Natural Resources Conservation Service (NRCS)11-2 p.m. Live with New Mexico State University Plant and Environmental Sciences11-3 Live with the American Chemical Society 11:30 a.m. Live with the Superintendent of Los Alamos Public Schools 11:30 a.m. Live with UNM-LA Computer Science Faculty12:30-12:45 p.m. Live with Be Greater Than Average 12:30-1:30 p.m. Live with the Bradbury Science Museum 1:00-1:40 p.m. Live with Science Girl’s Lab1:00 Live with a Docent from the National Museum of Nuclear Science & History1:30-2:00 p.m. Live with Los Alamos Public Schools – “Where in the World is Topper?”2:00 p.m. Live with PBS Science Café – Animal Espionage on the Pajarito Plateau2:30 p.m. Live with STEM Santa FeThis list is not inclusive of all exhibitors, so attendees are encouraged to use the app to visit the virtual exhibitor booths. The free app may be downloaded from Whova, or attendees may use the desktop app, which is a 2-step verification process. Users must first register via Eventbrite and then click “Attend Virtually” on the ScienceFest homepage and create an event account using the same registration email. There may be a slight delay in verification between platforms.For questions or concerns, contact lauren@losalamos.org or jeremy@losalamos.org. More information may be found on www.LosAlamosScienceFest.com, and participants are encouraged to share photos using the hashtag, #LosAlamosScienceFest2020 for a chance to win cool prizes from the Los Alamos History Museum, American Chemical Society and more!Los Alamos ScienceFest 2020 is made possible thanks to generous sponsors:Los Alamos County, Enterprise Bank & Trust, Del Norte Credit Union, TechSource, UNM-LA, and UbiQD, as well as dozens of local partners and organizations.last_img read more

Read More »

Whitehall turns a blind eye to fallout from legal aid cuts

first_imgIt is a common cry, when a decision goes against someone, that there was a flaw in consultation. But the objections to what is proposed for the withdrawal of legal aid in the Legal Aid Sentencing and Punishment of Offenders Bill are more substantive than the lamentations of sore losers. The 5,000-odd submissions to the government’s legal aid consultation did much more than register opposition to proposed cuts in provision. Many also contained eloquent, practical and detailed explanations of the wider consequences of the cuts proposed.These were consequences for expenditure that would be incurred elsewhere in the public sector; for the rights of individuals affected; and for standards of bodies who would not be held to account by publicly funded litigants. Kenneth Clarke has chosen to ignore these points. In doing so, he, fellow ministers and civil servants are taking public policy into territory that shares a long border with malfeasance in public office. The withdrawal of legal aid from scope for the areas proposed does not result from negligence or incompetence. It is deliberate and doctrinaire, and turns a wilful blind eye to the consequences and costs of the policy, as identified in those submissions. In withdrawing legal aid on this scale, the government fails in one of its key duties – namely to provide a balanced and independent mechanism for sustaining access to justice for all. This is a shameful bill.last_img read more

Read More »

Crowded house

first_imgTo continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Subscribe now for unlimited access Get your free guest access  SIGN UP TODAYlast_img read more

Read More »

Safety slip

first_imgGet your free guest access  SIGN UP TODAY To continue enjoying Building.co.uk, sign up for free guest accessExisting subscriber? LOGIN Stay at the forefront of thought leadership with news and analysis from award-winning journalists. Enjoy company features, CEO interviews, architectural reviews, technical project know-how and the latest innovations.Limited access to building.co.ukBreaking industry news as it happensBreaking, daily and weekly e-newsletters Subscribe to Building today and you will benefit from:Unlimited access to all stories including expert analysis and comment from industry leadersOur league tables, cost models and economics dataOur online archive of over 10,000 articlesBuilding magazine digital editionsBuilding magazine print editionsPrinted/digital supplementsSubscribe now for unlimited access.View our subscription options and join our community Subscribe now for unlimited accesslast_img read more

Read More »

Jumbo in export terminal project (video)

first_imgWork on the project began in May of this year, with the first of six consecutive transportations of large and heavy equipment from China to Australia, using Jumbo’s multipurpose vessel, Fairpartner.The largest piece of equipment shipped by Jumbo’s J-class vessels during the project was a 537-tonne and 126 m long stacker bridge, for which a project specific lifting frame was developed to ensure safe handling of the cargo.The shipments have consisted of wharf decks, as well as gantries, which were stacked and transported with as many as seven being carried in one go.Jumbo’s in house engineering team was also responsible for the design of a set of lifting beams capable of handling eight modules of differing sizes and weights.Jumbo’s involvement with the project is set to continue next year with the transportation of the final set of wharf decks, and the final transportation of the shiploader, with a total weight of 1,200 tonnes and the dimensions 76.5 m x 48 m x 28.5 m, from Port Klang in Malaysia.  Watch a video of the Jumbo Jubilee lifting and discharging a wharf deck here:  www.jumbomaritime.nllast_img read more

Read More »

Update on clinical negligence fixed costs: No update

first_imgThe Department of Health has updated its review of fixed recoverable costs on claims against the NHS in England and Wales – to say there is still no decision.A consultation on the introduction of the fees opened in January and closed on 2 May, with a response expected before last week’s summer parliamentary recess.That date passed without any statement, and now the DoH has ‘updated’ the consultation page to say decisions on development of this policy ‘have not yet been finalised’ following the formation of a new government last month. The results of the consultation, adds the update, will be published ‘in due course’.The lack of action leaves lawyers involved in clinical negligence claims still unsure where they stand and what future plans they should make. Lawyers were asked for their thoughts in a pre-consultation as long ago as 2015, but progress has stalled since then.The DoH says the scheme aims to provide quicker and more cost effective resolution for all parties, greater opportunities for earlier learning of lessons and access to justice by streamlining the system and incentivising earlier resolution of claims.The department has stated the current system of claims is ‘often lengthy, adversarial and the escalating the costs of litigation is not sustainable’.Helen Vernon, NHS Resolution chief executive, said last month that claimant legal costs rising 19% from £418m to £498.5m illustrated the ongoing challenge of ‘disproportionate’ fees.The issue could be complicated further next week when Lord Justice Jackson is due to publish his report on fixed recoverable costs for all civil justice claims. The Court of Appeal judge has gone on record with doubts about applying a fixed costs regime to multi-track clinical negligence claims valued more than £25,000.last_img read more

Read More »

Former Springbok Chiliboy Ralepelle banned for 8 years for doping

first_imgSouth African rugby player Mahlatse Ralepelle, popularly known as Chiliboy, who was found guilty of doping and subsequently banned for eight years. PHOTO: AFPFormer Springbok and Sharks hooker Mahlatse Ralepelle was handed an eight-year ban after testing positive for a banned substance last year.Ralepelle, popularly knowns as Chiliboy, tested positive for Zeranol, an anabolic agent, during an out-of-competition test on January 17 2019.This was the 33-year-old’s third positive doping test during his playing career within a 10-year period. Ralepelle, a repeat offender, had previously tested positive on two different occasions, in 2010 and 2015, while playing overseas.“The athlete challenged the doping charge and was afforded the opportunity to seek legal counsel to present his case and version of events to the tribunal panel.  The hearings were adjourned multiple times and were held over a period of six months.  The panel reached a decision first on the merits of the case where they found the player guilty of a doping offense,” the South African Institute for Drug-Free Sport (SAIDS) said.Ralepelle has 21 days appeal against the decision by the Independent Doping Tribunal Pane which runs until January 2027.The former Springbok told local publication News24 that though he and his team were trying to figure out how to move forward, this was not how he had envisioned his career ending.“Once we have all of those on the table, then it will make it easier for one to make a decision, whether you go ahead with the appeal or you stand back and move on with life,” Ralepelle told News24.“At the end of the day, whether it’s four or eight years, it’s the end of my career.”Ralepelle, who warned athletes to be extra careful and protect themselves, hinted that he was looking beyond rugby and possibly concentrating on his studies.“I need to get back out there in terms of furthering my studies and so on. I am looking forward to moving on to a completely new chapter outside of sport, which is what I’ve known my whole life.”Ralepelle made his Test debut for South Africa in 2006 against New Zealand in Pretoria while his final appearance was in a 25-10 defeat to England in Cape Town in June 2018.Related Kenyan marathoner Felix Kirwa banned for 9 months for doping Former Kenyan athlete Martin Keino on dopingcenter_img Kenya could be banned from Rio games over doping allegationslast_img read more

Read More »

Jamaican artiste denied entry into Dominica

first_img Share Tweet Sharing is caring! EntertainmentLocalNewsRegional Jamaican artiste denied entry into Dominica by: – February 23, 2014 Sharecenter_img 73 Views   4 comments Share Sparta posted this photograph on Facebook with the caption, “Me nah leave tonight Let through mi lawyer Tehani Behanzin me need to see him right ya now”Organizer of a concert featuring Jamaican artiste Tommy Lee Sparta, Cabral Douglas has confirmed that the artiste has been denied entry into the country.Douglas, who confirmed to Dominica Vibes on Sunday evening that the artiste had been denied entry, did not wish to comment further as he was seeking clarification from the immigration authority the reason for the decision.Douglas noted however that the artiste had not been allowed legal counsel although he provided one for him at the airport and that the authorities were seeking to deport the artiste.Tommy Lee Sparta posted a photograph on his Facebook page; “I am a CARICOM citizen. What Dominica a deal wid? Mi lawyer ah deal wid dis right away! The people them request me and them have rights too”.“So them don’t respect Jamaicans? What them a deal wid? Sparta a go protest right about now!,” he also posted.It is not clear at this time whether this decision by the Immigration Department is related to written request by the Northern Pastors Fellowship.Photograph posted by Tommy Lee Sparta on Facebook on Sunday, February 23, 2014Dominica Vibes has been reliably informed that the Fellowship wrote to the government weeks ago and requested that the artiste not be allowed to perform here.They also held a march against Tommy Lee in Portsmouth on Sunday, February 9 in collaboration with churches and the Dominica Association of Evangelical Churches (DAEC).The DAEC also issued a statement on February 7, 2014 calling on citizens to boycott the concert, claiming that his lyrics “promote violence, a phenomenon that we are currently grappling with in our nation”.“The current pattern of crime and violence in Dominica is of significant concern and provides us with an enormous challenge that further inspiration in crime and violence is unwanted,” the statement added.The concert, which was originally carded for last Sunday, February 16, 2014 was postponed after Sparta who had been in police custody, missed his flight. Sparta has been in police custody since February 3 on suspected breaches of the Law Reform (Fraudulent Transaction) (Special Provisions) Act, 2013 in Jamaica, was charged and released on bail on Friday, February 14.Dominica Vibes Newslast_img read more

Read More »